Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 19/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.51 |
| ▸ | PLG | P00747 | 2/20 | 0.48 |
| ▸ | KLK1 | P06870 | 2/20 | 0.48 |
| ▸ | PROC | P04070 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 3/20 | 0.47 |
| ▸ | PLAT | P00750 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7601136 | 0.93 | F10 (0.58) | F10PRSS1PLGKLK1PROC | |
| SCHEMBL7006031 | 0.91 | F10 (0.52) | F10PRSS1PLGKLK1PROC | |
| SCHEMBL7008413 | 0.88 | F10 (0.64) | F10PRSS1F2PRSS2PRSS3 | |
| SCHEMBL6298708 | 0.88 | F10 (0.45) | F10PRSS1PLGKLK1PROC | |
| SCHEMBL6298709 | 0.86 | F10 (0.67) | F10PRSS1PLGKLK1PROC | |
| SCHEMBL7116332 | 0.84 | F10 (0.59) | F10PRSS1PLGKLK1PROC | |
| SCHEMBL7598438 | 0.84 | F10 (0.59) | F10PRSS1PLGKLK1PROC | |
| SCHEMBL7120712 | 0.82 | F10 (0.62) | F10PRSS1PLGKLK1PROC | |
| SCHEMBL7600812 | 0.81 | F10 (0.72) | F10PRSS1PLGPROCPRSS2 | |
| SCHEMBL7114688 | 0.81 | F10 (0.60) | F10PRSS1PLGKLK1PROC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268413-A2 | SUBSTITUTED BIPHENYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070678-A2 | SUBSTITUTED BIPHENYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2001-09-27 | — | — | WO | disclosed |