Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.76 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
| ▸ | PDE1A | P54750 | 2/20 | 0.56 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.56 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.56 |
| ▸ | PDE2A | O00408 | 1/20 | 0.56 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.56 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.56 |
| ▸ | PDE6D | O43924 | 1/20 | 0.56 |
| ▸ | PDE8A | O60658 | 1/20 | 0.56 |
| ▸ | PDE9A | O76083 | 1/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | PDE6A | P16499 | 1/20 | 0.56 |
| ▸ | PDE6G | P18545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL7012672 | 0.97 | PDE5A (0.78) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| SCHEMBL6501252 | 0.97 | PDE5A (0.80) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| SCHEMBL6506281 | 0.93 | PDE5A (0.80) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| Sulfuric Acid SCHEMBL6499390 | 0.90 | PDE5A (0.80) | PDE5A | |
| Sulfuric Acid SCHEMBL6644361 | 0.89 | PDE5A (0.76) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| SCHEMBL22066547 | 0.89 | PDE5A (0.80) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| SCHEMBL6529760 | 0.89 | PDE5A (0.84) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| SCHEMBL6485584 | 0.88 | PDE5A (0.81) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL6641810 | 0.88 | PDE5A (0.82) | PDE5APDE3BPDE3AHDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL6502773 | 0.88 | PDE5A (0.73) | PDE5APDE3BPDE3AHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362858-A1 | Pyrrolopyrimidinone derivates, process of preparation and use | SK Chemicals Co., Ltd. (KR) | 2003-11-19 | — | — | EP | disclosed |