Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.81 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.76 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.76 |
| ▸ | PDE1A | P54750 | 5/20 | 0.70 |
| ▸ | PDE1B | Q01064 | 5/20 | 0.70 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.70 |
| ▸ | PDE2A | O00408 | 1/20 | 0.63 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.63 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.63 |
| ▸ | PDE6D | O43924 | 1/20 | 0.63 |
| ▸ | PDE8A | O60658 | 1/20 | 0.63 |
| ▸ | PDE9A | O76083 | 1/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | HTR1A | P08908 | 1/20 | 0.63 |
| ▸ | PDE6A | P16499 | 1/20 | 0.63 |
| ▸ | PDE6G | P18545 | 1/20 | 0.63 |
| ▸ | PDE4A | P27815 | 1/20 | 0.63 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.63 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6643457 | 0.99 | PDE5A (0.80) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL31651391 | 0.95 | PDE5A (0.81) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL6501107 | 0.95 | PDE5A (0.81) | PDE5APDE3BPDE3APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL6641108 | 0.95 | PDE5A (0.80) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL6483207 | 0.95 | PDE5A (0.88) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL6529760 | 0.95 | PDE5A (0.84) | PDE5APDE3BPDE3APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL6646062 | 0.94 | PDE5A (0.79) | PDE5APDE3BPDE3APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL6643786 | 0.94 | PDE5A (0.86) | PDE5APDE3BPDE3APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL6641810 | 0.94 | PDE5A (0.82) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL6475482 | 0.93 | PDE5A (0.90) | PDE5APDE3BPDE3APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9271916-B2 | Composition for reducing skin wrinkles including PDE5 inhibitor | SK CHEMICALS CO., LTD. (KR) | 2016-03-01 | — | — | US | claimed |
| US-20140187775-A1 | COMPOSITION FOR REDUCING SKIN WRINKLES INCLUDING PDE5 INHIBITOR | SK CHEMICALS CO., LTD. (KR) | 2014-07-03 | — | — | US | claimed |
| WO-2013036081-A2 | COMPOSITION FOR REDUCING SKIN WRINKLES INCLUDING PDE5 INHIBITOR | SK CHEMICALS CO., LTD. (KR) | 2013-03-14 | — | — | WO | claimed |
| US-6962911-B2 | Pyrrolopyrimidinone derivatives, process of preparation and use | SK CHEMICALS CO., LTD. (KR) | 2005-11-08 | — | — | US | claimed |
| EP-1257553-B1 | PYRROLOPYRIMIDINONE DERIVATIVES, PROCESS OF PREPARATION AND USE | SK CHEMICALS CO LTD (KR) | 2004-05-26 | — | — | EP | claimed |
| US-20030171361-A1 | Pyrrolopyrimidinone derivatives, process of preparation and use | SK CHEMICALS CO., LTD. (KR) | 2003-09-11 | — | — | US | claimed |
| EP-4696376-A2 | NOVEL DUAL MODE OF ACTION SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | Topadur Pharma AG (CH) | 2026-02-18 | — | — | EP | disclosed |
| EP-3630769-B1 | NOVEL DUAL MODE OF ACTION SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | TOPADUR PHARMA AG (CH) | 2025-07-02 | — | — | EP | disclosed |
| US-20240360136-A1 | DUAL MODE OF ACTION SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | TOPADUR PHARMA AG (CH) | 2024-10-31 | — | — | US | disclosed |
| US-11905293-B2 | Dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof | TOPADUR PHARMA AG (CH) | 2024-02-20 | — | — | US | disclosed |
| US-20220073529-A1 | DUAL MODE OF ACTION SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | TOPADUR PHARMA AG (CH) | 2022-03-10 | — | — | US | disclosed |
| US-20220073529-A1 | DUAL MODE OF ACTION SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | TOPADUR PHARMA AG (CH) | 2022-03-10 | — | — | US | disclosed |
| US-11155558-B2 | Dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof | TOPADUR PHARMA AG (CH) | 2021-10-26 | — | — | US | disclosed |
| US-20200181149-A1 | NOVEL DUAL MODE OF ACTION SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | TOPADUR PHARMA AG (CH) | 2020-06-11 | — | — | US | disclosed |
| US-9271916-B2 | Composition for reducing skin wrinkles including PDE5 inhibitor | SK CHEMICALS CO., LTD. (KR) | 2016-03-01 | — | — | US | disclosed |
| US-20140187775-A1 | COMPOSITION FOR REDUCING SKIN WRINKLES INCLUDING PDE5 INHIBITOR | SK CHEMICALS CO., LTD. (KR) | 2014-07-03 | — | — | US | disclosed |
| WO-2013036081-A2 | COMPOSITION FOR REDUCING SKIN WRINKLES INCLUDING PDE5 INHIBITOR | SK CHEMICALS CO., LTD. (KR) | 2013-03-14 | — | — | WO | disclosed |
| US-20050130983-A1 | Pyrrolopyrimidinone derivatives, process for preparation thereof, and method of using and composition comprising them | IN2GEN CO., LTD. (KR) | 2005-06-16 | — | — | US | disclosed |
| EP-1257553-B1 | PYRROLOPYRIMIDINONE DERIVATIVES, PROCESS OF PREPARATION AND USE | SK CHEMICALS CO LTD (KR) | 2004-05-26 | — | — | EP | disclosed |
| EP-1362858-A1 | Pyrrolopyrimidinone derivates, process of preparation and use | SK Chemicals Co., Ltd. (KR) | 2003-11-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030171361-A1 | Pyrrolopyrimidinone derivatives, process of preparation and use | CYP2C19, DHPS, SDHA | PDE5A 686/4885PDE3B 601/4885PDE3A 734/4885 |
| US-20220073529-A1 | DUAL MODE OF ACTION SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | PDE5A, PDE1A, PDE2A | PDE5A 1/4885PDE3B 9/4885PDE3A 4/4885 |
| US-11155558-B2 | Dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof | PDE7A, GNAO1, PDE3A | PDE5A 11/4885PDE3B 8/4885PDE3A 3/4885 |
| US-20200181149-A1 | NOVEL DUAL MODE OF ACTION SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | PDE7A, PDE3A, PDE9A | PDE5A 10/4885PDE3B 8/4885PDE3A 2/4885 |
| US-11905293-B2 | Dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof | PDE5A, PDE1A, PDE2A | PDE5A 1/4885PDE3B 9/4885PDE3A 4/4885 |
| US-20240360136-A1 | DUAL MODE OF ACTION SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | PDE5A, PDE1A, PDE2A | PDE5A 1/4885PDE3B 9/4885PDE3A 4/4885 |
| US-20050130983-A1 | Pyrrolopyrimidinone derivatives, process for preparation thereof, and method of using and composition comprising them | DHPS, SDHA, FDPS | PDE5A 582/4885PDE3B 330/4885PDE3A 479/4885 |
| US-20140187775-A1 | COMPOSITION FOR REDUCING SKIN WRINKLES INCLUDING PDE5 INHIBITOR | PDE5A, PDE3B, PDE3A | PDE5A 1/4885PDE3B 2/4885PDE3A 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.