Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 8/20 | 0.35 |
| ▸ | JAK2 | O60674 | 7/20 | 0.35 |
| ▸ | JAK1 | P23458 | 4/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 4/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013004 | 0.90 | AKT1 (0.36) | JAK3JAK2JAK1AKT1SIRT2 | |
| SCHEMBL7011382 | 0.88 | JAK3 (0.39) | JAK3JAK2JAK1AKT1SIRT2 | |
| SCHEMBL7011098 | 0.87 | JAK2 (0.37) | JAK3JAK2JAK1AKT1SIRT2 | |
| SCHEMBL7017463 | 0.85 | JAK3 (0.38) | JAK3JAK2JAK1AKT1SIRT2 | |
| SCHEMBL7018651 | 0.84 | AOC3 (0.35) | LCKKDR | |
| SCHEMBL7011716 | 0.84 | JAK3 (0.39) | JAK3JAK2JAK1AKT1SIRT2 | |
| SCHEMBL7016210 | 0.84 | JAK3 (0.36) | JAK3JAK2JAK1AKT1SIRT2 | |
| SCHEMBL7012012 | 0.82 | SLC6A9 (0.35) | JAK3JAK2MET | |
| SCHEMBL7015911 | 0.81 | NPY1R (0.35) | JAK3JAK2JAK1AKT1TTK | |
| SCHEMBL7011245 | 0.80 | NPY1R (0.51) | JAK3JAK2JAK1AKT1NPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889034-B1 | AMINOPYRIDINE DERIVATIVES | BANYU PHARMA CO LTD (JP) | 2003-09-17 | — | — | EP | disclosed |
| US-6011039-A | USEFUL AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS; TREATING HYPERPHAGIA, OBESITY OR DIABETES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2000-01-04 | — | — | US | disclosed |
| EP-0889034-A1 | AMINOPYRIDINE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1999-01-07 | — | — | EP | disclosed |