Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7016046 | 0.95 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL6605220 | 0.85 | KMT2A (0.42) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7014973 | 0.80 | PDE4D (0.65) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7015082 | 0.79 | MAPT (0.45) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7011671 | 0.78 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL6604037 | 0.78 | KMT2A (0.38) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7015228 | 0.78 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7016905 | 0.77 | MAPT (0.43) | MAPTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL7015963 | 0.75 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7881905 | 0.74 | PDE4D (0.58) | PDE4APDE4BPDE4CPDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086106-B1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LTD (GB) | 2003-08-20 | — | — | EP | disclosed |
| US-6169090-B1 | FOR INHIBITION OF PHOSPHODIESTERASE IV | DARWIN DISCOVERY, LTD. (GB) | 2001-01-02 | — | — | US | disclosed |