Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 15/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.65 |
| ▸ | PDE4A | P27815 | 10/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7881905 | 0.94 | PDE4D (0.58) | PDE4DPDE4BPDE4APDE4CMAPT | |
| SCHEMBL7011316 | 0.93 | PDE4D (0.64) | PDE4DPDE4BPDE4APDE4CMAPT | |
| SCHEMBL7017070 | 0.81 | PDE4A (0.54) | PDE4DPDE4BPDE4APDE4CGCK | |
| SCHEMBL7013236 | 0.80 | PDE4A (0.55) | PDE4DPDE4BPDE4APDE4CMAPT | |
| SCHEMBL6606553 | 0.80 | PDE4D (0.49) | PDE4DPDE4BPDE4APDE4CMAPT | |
| SCHEMBL7020524 | 0.74 | PDE4D (0.52) | PDE4DPDE4BPDE4APDE4CPIK3CA | |
| SCHEMBL7016046 | 0.73 | PDE4A (0.54) | PDE4DPDE4BPDE4APDE4CMAPT | |
| SCHEMBL7012791 | 0.72 | PDE4A (0.45) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7017344 | 0.72 | PDE4A (0.52) | PDE4DPDE4BPDE4APDE4CGCK | |
| SCHEMBL7010243 | 0.72 | PDE4A (0.46) | PDE4DPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086106-B1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LTD (GB) | 2003-08-20 | — | — | EP | claimed |
| EP-1086106-A1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | Darwin Discovery Limited (GB) | 2001-03-28 | — | — | EP | claimed |
| WO-1999064423-A1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LIMITED (GB) | 1999-12-16 | — | — | WO | claimed |
| EP-1086106-B1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LTD (GB) | 2003-08-20 | — | — | EP | disclosed |
| EP-1086106-A1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | Darwin Discovery Limited (GB) | 2001-03-28 | — | — | EP | disclosed |
| US-6169090-B1 | FOR INHIBITION OF PHOSPHODIESTERASE IV | DARWIN DISCOVERY, LTD. (GB) | 2001-01-02 | — | — | US | disclosed |
| WO-1999064423-A1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LIMITED (GB) | 1999-12-16 | — | — | WO | disclosed |