Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 9/20 | 0.64 |
| ▸ | HTR1A | P08908 | 7/20 | 0.60 |
| ▸ | HTR1D | P28221 | 6/20 | 0.60 |
| ▸ | HTR1B | P28222 | 6/20 | 0.60 |
| ▸ | NOS3 | P29474 | 2/20 | 0.48 |
| ▸ | NOS1 | P29475 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR1E | P28566 | 1/20 | 0.48 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7004660 | 0.90 | HTR1F (0.79) | HTR1FHTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL7012793 | 0.86 | HTR1F (0.76) | HTR1FHTR1AHTR1DHTR1B | |
| SCHEMBL8457517 | 0.83 | HTR1F (0.56) | HTR1FHTR1AHTR1DHTR1BNOS3 | |
| SCHEMBL7009808 | 0.83 | HTR1F (0.62) | HTR1FHTR1AHTR1DHTR1BNOS3 | |
| SCHEMBL7016665 | 0.81 | HTR1F (0.48) | HTR1FHTR1AHTR1DHTR1BNOS3 | |
| SCHEMBL7007093 | 0.79 | HTR1F (0.83) | HTR1FHTR1AHTR1DHTR1BNOS3 | |
| SCHEMBL7012929 | 0.79 | HTR1F (0.51) | HTR1FHTR1AHTR1DHTR1BNOS3 | |
| SCHEMBL7012389 | 0.78 | HTR1F (0.50) | HTR1FHTR1ANOS3NOS1 | |
| SCHEMBL7013847 | 0.78 | HTR1F (1.00) | HTR1FHTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL30909151 | 0.77 | HTR1F (0.53) | HTR1FHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842934-B1 | 5-HT1F agonists | LILLY CO ELI (US) | 2003-10-29 | — | — | EP | disclosed |
| EP-1082958-A2 | 5-HT1F agonists in chronic pain | ELI LILLY AND COMPANY (US) | 2001-03-14 | — | — | EP | disclosed |
| US-5998622-A | ANALGESICS; ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION | ELI LILLY AND COMPANY (US) | 1999-12-07 | — | — | US | disclosed |
| US-5919936-A | 5-HT1F AGONIST INTERMEDIATES | ELI LILLY AND COMPANY (US) | 1999-07-06 | — | — | US | disclosed |
| US-5817671-A | ANTISEROTONIN AGENT; ANALGESICS; MIGRAINE THERAPY; COMPOUND CONTAINING PYRROLO(3,2-B)PYRIDINE RING | ELI LILLY AND COMPANY (US) | 1998-10-06 | — | — | US | disclosed |
| EP-0842934-A1 | 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-05-20 | — | — | EP | disclosed |