Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | PDE5A | O76074 | 2/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7020092 | 0.95 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7014926 | 0.92 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL8171864 | 0.89 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7012518 | 0.89 | ESR1 (0.42) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7020085 | 0.88 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7011351 | 0.88 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7018892 | 0.87 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7016750 | 0.87 | CNR1 (0.46) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7018811 | 0.87 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7011880 | 0.87 | CTNNB1 (0.45) | ALDH1A1KDM4ENPSR1HPGDCTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |
| EP-0934321-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GmbH (DE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017668-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 1998-04-30 | — | — | WO | disclosed |