Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 17/20 | 0.45 |
| ▸ | ITGB5 | P18084 | 15/20 | 0.45 |
| ▸ | ITGB6 | P18564 | 4/20 | 0.45 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.45 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.45 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013425 | 0.95 | ITGAV (0.47) | ITGAVITGB3ITGB5ITGB6ITGB1 | |
| SCHEMBL8479505 | 0.84 | ITGAV (0.49) | ITGAVITGB3ITGB5ITGB6ITGB1 | |
| SCHEMBL8479508 | 0.80 | ITGAV (0.49) | ITGAVITGB3ITGB5ITGB6ITGB1 | |
| SCHEMBL8483637 | 0.78 | ITGAV (0.47) | ITGAVITGB3ITGB5ITGB6ITGB1 | |
| SCHEMBL2383101 | 0.77 | ITGAV (0.44) | ITGAVITGB3ITGB5ITGB6ITGB1 | |
| SCHEMBL7009416 | 0.77 | ITGAV (0.41) | ITGAVITGB3ITGB5ITGB6ITGB1 | |
| SCHEMBL13712259 | 0.75 | ITGAV (0.53) | ITGAVITGB3ITGB5ITGB6ITGB1 | |
| SCHEMBL2376065 | 0.75 | ITGAV (0.49) | ITGAVITGB6 | |
| SCHEMBL8483640 | 0.74 | ITGAV (0.47) | ITGAVITGB3ITGB5ITGB6ITGB1 | |
| SCHEMBL22893614 | 0.73 | ITGAV (0.38) | ITGAVITGB3ITGB5ITGB6ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946165-B1 | INTEGRIN ANTAGONISTS | MERCK & CO INC (US) | 2003-04-09 | — | — | EP | disclosed |
| EP-0946165-A4 | INTEGRIN ANTAGONISTS | MERCK & CO INC (US) | 2001-04-11 | — | — | EP | disclosed |
| EP-0946165-A1 | INTEGRIN ANTAGONISTS | Merck & Co., Inc. (US) | 1999-10-06 | — | — | EP | disclosed |
| US-5952341-A | VITRONECTIN RECEPTOR ANTAGONISTS FOR INHIBITING BONE RESORPTION, TREATING AND PREVENTING OSTEOPOROSIS, AND INHIBITING RESTENOSIS, DIABETIC RETINOPATHY, TUMOR, MACULAR DEGENERATION, ANGIOGENESIS, ATHEROSCLEROSIS, INFLAMMATION | MERCK & CO., INC. (US) | 1999-09-14 | — | — | US | disclosed |
| WO-1998018460-A1 | INTEGRIN ANTAGONISTS | MERCK & CO., INC. (US) | 1998-05-07 | — | — | WO | disclosed |