Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | TYMS | P04818 | 7/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | HTR3A | P46098 | 2/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7011304 | 0.79 | SMN1; SMN2 (0.44) | IDO1DAONOTUMTYMSHTR1A | |
| SCHEMBL9488631 | 0.70 | AR (0.46) | IDO1NOTUMHTR1AHTR3ASMN1; SMN2 | |
| SCHEMBL7013173 | 0.70 | TYMS (0.32) | IDO1DAOTYMSMCL1 | |
| SCHEMBL13915410 | 0.69 | AR (0.45) | IDO1NOTUMHTR1AHTR3ASMN1; SMN2 | |
| SCHEMBL29543680 | 0.68 | ACHE (0.58) | IDO1NOTUMDDB1CRBNHTR1A | |
| SCHEMBL29468631 | 0.68 | ACHE (0.58) | IDO1NOTUMDDB1CRBNHTR1A | |
| SCHEMBL575896 | 0.68 | ACHE (0.58) | IDO1NOTUMDDB1CRBNHTR1A | |
| SCHEMBL11617247 | 0.68 | IDO1 (0.50) | IDO1DAONOTUMPRMT5WDR77 | |
| SCHEMBL10348868 | 0.67 | ACHE (0.46) | IDO1NOTUMDDB1CRBNHTR1A | |
| SCHEMBL9488559 | 0.66 | ACHE (0.41) | IDO1NOTUMHTR1AHTR3ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0843663-B9 | 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES | CENTRE NAT RECH SCIENT (FR) | 2003-10-29 | — | — | EP | disclosed |
| EP-0843663-B1 | 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES | CENTRE NAT RECH SCIENT (FR) | 2003-04-09 | — | — | EP | disclosed |
| WO-1997005113-A1 | 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 1997-02-13 | — | — | WO | disclosed |