Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 18/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 18/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.76 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6354270 | 0.91 | CYP3A4 (0.60) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL6062184 | 0.86 | CYP3A4 (1.00) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL7600893 | 0.83 | CYP3A4 (0.72) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19 | |
| Hydrochloric Acid SCHEMBL6360648 | 0.82 | CYP3A4 (0.79) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL7008301 | 0.82 | CYP3A4 (0.62) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL7009452 | 0.81 | CYP3A4 (0.70) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL7100471 | 0.81 | CYP3A4 (0.50) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL7010258 | 0.80 | CYP3A4 (0.53) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL7016930 | 0.80 | CYP3A4 (0.56) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL7100473 | 0.80 | CYP3A4 (0.49) | CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6613775-B1 | 8-(2,6-dimethylbenzylamino)-2-hydroxymethyl-3-methylimidazo(1, 2-a)pyridine used as antisecretory agents for prophylaxis of gastrointestinal disorders such as ulcers | ASTRAZENECA AB (SE) | 2003-09-02 | — | — | US | claimed |
| EP-1105390-B1 | Imidazo[1,2-a]pyridine derivatives for the treatment of gastrointestinal diseases | ASTRAZENECA AB (SE) | 2003-06-04 | — | — | EP | claimed |
| EP-1105390-A2 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2001-06-13 | — | — | EP | claimed |
| WO-2000010999-A2 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2000-03-02 | — | — | WO | claimed |
| US-6613775-B1 | 8-(2,6-dimethylbenzylamino)-2-hydroxymethyl-3-methylimidazo(1, 2-a)pyridine used as antisecretory agents for prophylaxis of gastrointestinal disorders such as ulcers | ASTRAZENECA AB (SE) | 2003-09-02 | — | — | US | disclosed |
| EP-1105390-B1 | Imidazo[1,2-a]pyridine derivatives for the treatment of gastrointestinal diseases | ASTRAZENECA AB (SE) | 2003-06-04 | — | — | EP | disclosed |
| EP-1105390-A2 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2001-06-13 | — | — | EP | disclosed |
| WO-2000010999-A2 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2000-03-02 | — | — | WO | disclosed |