SCHEMBL7600893

SCHEMBL7600893

CCc1cccc(C)c1CNc1cccn2c(C)c(C(N)=O)nc12

nearest known ligand 0.72

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 15/20 0.72
CYP2C9 P11712 13/20 0.72
CYP2D6 P10635 7/20 0.72
CYP1A2 P05177 5/20 0.72
CYP2C19 P33261 5/20 0.72
CD38 P28907 4/20 0.42
KCNH2 Q12809 1/20 0.42
JAK2 O60674 1/20 0.38
JAK1 P23458 1/20 0.38
TYK2 P29597 1/20 0.38
JAK3 P52333 1/20 0.38
CASP1 P29466 1/20 0.36
CASP7 P55210 1/20 0.36
HSD17B10 Q99714 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7009452 0.88 CYP3A4 (0.70) CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19
SCHEMBL6062184 0.84 CYP3A4 (1.00) CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19
SCHEMBL7013524 0.83 CYP3A4 (0.76) CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19
SCHEMBL6360390 0.81 CYP3A4 (0.59) CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19
SCHEMBL8184990 0.79 CYP3A4 (0.70) CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19
SCHEMBL7500392 0.78 CYP3A4 (0.88) CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19
SCHEMBL6351859 0.77 CYP3A4 (0.57) CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19
SCHEMBL5008604 0.77 CYP3A4 (0.50) CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19
SCHEMBL6360269 0.77 CYP3A4 (0.80) CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19
SCHEMBL29405170 0.76 CYP3A4 (1.00) CYP3A4CYP2C9CYP2D6CYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002060440-A1 NOVEL FORMS OF 2,3-DIMETHYL-8-(2-ETHYL-6-METHYLBENZYLAMINO)-IMIDAZO (1,2-A)PYRIDINE-6-CARBOXAMIDE ASTRAZENECA AB (SE) 2002-08-08 WO disclosed