SCHEMBL7013596

SCHEMBL7013596

CCC(=O)NCc1cccn1-c1ccc(Cl)c(COc2cccc3c(-n4ccnc4)cc(C)nc23)c1Cl

nearest known ligand 0.72

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 17/20 0.72
RORC P51449 3/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7007129 0.93 BDKRB2 (0.73) BDKRB2RORC
SCHEMBL7007786 0.85 BDKRB2 (0.88) BDKRB2
SCHEMBL7007781 0.85 BDKRB2 (0.88) BDKRB2
SCHEMBL7013778 0.85 BDKRB2 (0.85) BDKRB2
SCHEMBL7013780 0.85 BDKRB2 (0.85) BDKRB2
SCHEMBL7013275 0.85 BDKRB2 (0.81) BDKRB2
SCHEMBL7013281 0.85 BDKRB2 (0.81) BDKRB2
SCHEMBL7007742 0.85 BDKRB2 (0.78) BDKRB2
SCHEMBL7007749 0.85 BDKRB2 (0.78) BDKRB2
SCHEMBL7009398 0.84 BDKRB2 (0.86) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0861243-B1 HETEROCYCLIC COMPOUNDS AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO (JP) 2003-11-12 EP disclosed
US-6344462-B1 Heterocyclic compounds as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-02-05 US disclosed
US-6100284-A ANTIALLERGENS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-08-08 US disclosed
US-6008229-A TREATING ALLERGY, INFLAMMATION, AUTOIMMUNE DISEASE, SHOCK, PAIN FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-12-28 US disclosed
EP-0861243-A1 HETEROCYCLIC COMPOUNDS AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-09-02 EP disclosed
WO-1997011069-A1 HETEROCYCLIC COMPOUNDS AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-03-27 WO disclosed