Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 2/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 10/20 | 0.41 |
| ▸ | TCF7L2 | Q9NQB0 | 10/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019165 | 0.93 | HRH4 (0.45) | HRH4CTNNB1TCF7L2 | |
| SCHEMBL7008973 | 0.92 | KMT2A (0.42) | EPHX2HRH4HTR3APDE5ACTNNB1 | |
| SCHEMBL7012162 | 0.92 | ALDH1A1 (0.44) | EPHX2HRH4PDE5ACTNNB1TCF7L2 | |
| SCHEMBL7018489 | 0.90 | PDE4A (0.39) | HRH4PDE5ACTNNB1TCF7L2PDE4A | |
| SCHEMBL8170901 | 0.89 | EPHX2 (0.46) | EPHX2HRH4HTR3APDE5ACTNNB1 | |
| SCHEMBL7018546 | 0.88 | JAK2 (0.40) | HRH4PDE5AKDM4EDRD3 | |
| SCHEMBL7019915 | 0.88 | PDE5A (0.42) | PDE5A | |
| SCHEMBL8181495 | 0.87 | MAPT (0.48) | EPHX2CTNNB1TCF7L2MAPTNPSR1 | |
| SCHEMBL7018507 | 0.87 | PDE5A (0.48) | PDE5A | |
| SCHEMBL7017154 | 0.86 | PDE4A (0.54) | PDE5ACTNNB1TCF7L2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |