Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 3/20 | 0.40 |
| ▸ | AXL | P30530 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 5/20 | 0.37 |
| ▸ | JAK1 | P23458 | 5/20 | 0.37 |
| ▸ | TYK2 | P29597 | 5/20 | 0.37 |
| ▸ | JAK3 | P52333 | 5/20 | 0.37 |
| ▸ | USP5 | P45974 | 1/20 | 0.37 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | CIT | O14578 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23505912 | 0.77 | PRKCI (0.43) | PRKCIAXLJAK2JAK1TYK2 | |
| SCHEMBL12411008 | 0.71 | MEN1 (0.45) | ADORA2A | |
| SCHEMBL7016895 | 0.71 | SMN1; SMN2 (0.47) | ADORA2A | |
| SCHEMBL2614340 | 0.69 | USP5 (0.69) | USP5 | |
| SCHEMBL14894316 | 0.68 | JAK2 (0.46) | PRKCIAXLJAK2JAK1TYK2 | |
| SCHEMBL21142493 | 0.68 | PDE4A (0.49) | USP5ADORA2A | |
| SCHEMBL12825983 | 0.68 | CYP1A2 (0.47) | USP5 | |
| SCHEMBL13258404 | 0.67 | ESR2 (0.56) | — | |
| SCHEMBL15723760 | 0.67 | MEN1 (0.41) | JAK2JAK1ADORA2A | |
| SCHEMBL20224878 | 0.67 | MEN1 (0.51) | JAK2ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4026832-A1 | PIPERIDINE DERIVATIVES AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 | Almac Discovery Limited (GB) | 2022-07-13 | — | — | EP | disclosed |
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| US-5753664-A | ANTITUMOR AGENTS, PYRIMIDONES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |