Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27578227 | 0.81 | ALDH1A1 (0.34) | MAPTSMN1; SMN2TSHRKDM4EHTT | |
| SCHEMBL166764 | 0.74 | CHRM5 (0.46) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL20292058 | 0.74 | CHRM5 (0.46) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL6179170 | 0.74 | CHRM5 (0.46) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL7012221 | 0.74 | MAPT (0.34) | MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7008410 | 0.73 | MEN1 (0.46) | SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL28189203 | 0.72 | CYP2D6 (0.54) | MAPTSMN1; SMN2TSHRKDM4EHTT | |
| SCHEMBL4599754 | 0.72 | MEN1 (0.45) | SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL7018605 | 0.71 | CHRM5 (0.56) | MAPTSMN1; SMN2KDM4EALDH1A1L3MBTL3 | |
| SCHEMBL27923750 | 0.71 | HTT (0.34) | MAPTTSHRKDM4EHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268431-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | Wyeth (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072711-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH (US) | 2001-10-04 | — | — | WO | disclosed |