Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 9/20 | 0.50 |
| ▸ | TOP2B | Q02880 | 9/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.47 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005848 | 0.83 | TOP2A (0.51) | TOP2ATOP2BMEN1KMT2AKCNH2 | |
| SCHEMBL7013113 | 0.81 | TOP2A (0.51) | TOP2ATOP2BMEN1KMT2AKCNH2 | |
| SCHEMBL7013459 | 0.79 | TOP2A (0.57) | TOP2ATOP2BMEN1KMT2AKCNH2 | |
| SCHEMBL7011115 | 0.78 | TOP2A (0.54) | TOP2ATOP2BMEN1KMT2AKCNH2 | |
| SCHEMBL7013054 | 0.78 | TOP2A (0.56) | TOP2ATOP2BMEN1KMT2AKCNH2 | |
| SCHEMBL7011279 | 0.78 | TOP2A (0.56) | TOP2ATOP2BKCNH2POLBGSK3B | |
| SCHEMBL7007612 | 0.78 | KDM4E (0.56) | TOP2ATOP2BMEN1KMT2AKCNH2 | |
| SCHEMBL8111016 | 0.78 | TOP2A (0.58) | TOP2ATOP2BMEN1KMT2AKCNH2 | |
| SCHEMBL7013977 | 0.75 | TOP2A (0.53) | TOP2ATOP2B | |
| SCHEMBL5868648 | 0.74 | GSK3B (0.60) | TOP2ATOP2BMEN1KMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775702-B1 | NOVEL QUINOLONE- OR NAPHTHYRIDONECARBOXYLIC ACID DERIVATIVE OR SALT THEREOF | TOYAMA CHEMICAL CO LTD (JP) | 2003-07-23 | — | — | EP | disclosed |
| US-5935952-A | ANTIBACTERIAL AGENT | TOYAMA CHEMICAL CO., LTD. (JP) | 1999-08-10 | — | — | US | disclosed |
| EP-0775702-A1 | NOVEL QUINOLONE- OR NAPHTHYRIDONECARBOXYLIC ACID DERIVATIVE OR SALT THEREOF | TOYAMA CHEMICAL CO., LTD. (JP) | 1997-05-28 | — | — | EP | disclosed |