Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 8/20 | 0.51 |
| ▸ | TOP2B | Q02880 | 8/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005848 | 0.87 | TOP2A (0.51) | TOP2ATOP2BKCNH2HRH3GSK3B | |
| SCHEMBL7008855 | 0.87 | TOP2A (0.65) | TOP2ATOP2BKCNH2HRH3GSK3B | |
| SCHEMBL7011715 | 0.85 | TOP2A (0.60) | TOP2ATOP2BKCNH2GSK3BPOLB | |
| SCHEMBL7012570 | 0.84 | TOP2A (0.67) | TOP2ATOP2BKCNH2GSK3BCACNA1F | |
| SCHEMBL7009271 | 0.82 | TOP2A (0.72) | TOP2ATOP2BKCNH2GSK3BPOLB | |
| SCHEMBL7014195 | 0.81 | TOP2A (0.50) | TOP2ATOP2BKCNH2HRH3GSK3B | |
| SCHEMBL7008936 | 0.79 | TOP2A (0.59) | TOP2ATOP2BKCNH2GSK3BPOLB | |
| SCHEMBL8111016 | 0.78 | TOP2A (0.58) | TOP2ATOP2BKCNH2HRH3GSK3B | |
| SCHEMBL4998732 | 0.78 | TOP2A (0.46) | TOP2ATOP2BKCNH2GSK3BPOLB | |
| SCHEMBL7009585 | 0.78 | TOP2A (0.57) | TOP2ATOP2BKCNH2GSK3BPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775702-B1 | NOVEL QUINOLONE- OR NAPHTHYRIDONECARBOXYLIC ACID DERIVATIVE OR SALT THEREOF | TOYAMA CHEMICAL CO LTD (JP) | 2003-07-23 | — | — | EP | disclosed |
| US-5935952-A | ANTIBACTERIAL AGENT | TOYAMA CHEMICAL CO., LTD. (JP) | 1999-08-10 | — | — | US | disclosed |
| EP-0775702-A1 | NOVEL QUINOLONE- OR NAPHTHYRIDONECARBOXYLIC ACID DERIVATIVE OR SALT THEREOF | TOYAMA CHEMICAL CO., LTD. (JP) | 1997-05-28 | — | — | EP | disclosed |