Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 9/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7009408 | 0.99 | RORC (0.44) | RORCCNR1CNR2L3MBTL3L3MBTL1 | |
| SCHEMBL7010997 | 0.89 | RORC (0.45) | RORCCNR1CNR2L3MBTL3L3MBTL1 | |
| SCHEMBL7007596 | 0.88 | RORC (0.46) | RORCCNR1CNR2ROCK2NPC1 | |
| SCHEMBL7008140 | 0.87 | RORC (0.45) | RORCCNR1CNR2ROCK2NPC1 | |
| Hydrochloric Acid SCHEMBL7847628 | 0.87 | RORC (0.45) | RORCCNR1CNR2ROCK2NPC1 | |
| SCHEMBL7013968 | 0.87 | TP53 (0.51) | RORCCNR1CNR2TP53NPC1 | |
| Hydrochloric Acid SCHEMBL7013467 | 0.86 | RORC (0.45) | RORCCNR1CNR2ROCK2NPC1 | |
| SCHEMBL7007154 | 0.86 | RORC (0.45) | RORCCNR1CNR2ROCK2 | |
| SCHEMBL7012579 | 0.86 | RORC (0.46) | RORCCNR1CNR2ROCK2NPC1 | |
| Hydrochloric Acid SCHEMBL7013981 | 0.86 | RORC (0.44) | RORCCNR1CNR2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | claimed |
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | disclosed |
| EP-1102769-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000008020-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-02-17 | — | — | WO | disclosed |