SCHEMBL7014333

SCHEMBL7014333

Cc1cccc2nc(SCc3ccc(C(=O)N4CCN(C)CC4)cc3)n(C)c(=O)c12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.49
LMNA P02545 2/20 0.49
SMN1; SMN2 Q16637 10/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
MEN1 O00255 5/20 0.47
KMT2A Q03164 5/20 0.47
ALDH1A1 P00352 5/20 0.44
HTT P42858 2/20 0.44
PKM P14618 1/20 0.44
TP53 P04637 2/20 0.44
TDP1 Q9NUW8 1/20 0.43
MAPT P10636 2/20 0.42
RAB9A P51151 1/20 0.42
PLA2G1B P04054 1/20 0.42
ATG4B Q9Y4P1 1/20 0.42
HRH3 Q9Y5N1 1/20 0.41
IDO1 P14902 1/20 0.41
TDO2 P48775 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7016083 0.97 HPGD (0.47) HPGDLMNASMN1; SMN2CYP3A4CYP2C9
SCHEMBL7016908 0.91 SMN1; SMN2 (0.46) HPGDLMNASMN1; SMN2CYP3A4CYP2C9
SCHEMBL7016066 0.91 MEN1 (0.47) HPGDLMNASMN1; SMN2CYP3A4CYP2C9
SCHEMBL7010368 0.91 SMN1; SMN2 (0.52) HPGDSMN1; SMN2CYP3A4CYP2C9CYP2C19
SCHEMBL7019981 0.91 TDP1 (0.48) SMN1; SMN2CYP3A4CYP2C9CYP2C19MEN1
SCHEMBL7015766 0.90 SMN1; SMN2 (0.49) HPGDLMNASMN1; SMN2CYP3A4CYP2C9
Hydrochloric Acid SCHEMBL7008846 0.89 SMN1; SMN2 (0.43) HPGDLMNASMN1; SMN2CYP3A4CYP2C9
SCHEMBL7018977 0.89 MEN1 (0.48) HPGDLMNASMN1; SMN2CYP3A4CYP2C9
SCHEMBL7008899 0.89 SLC6A7 (0.52) SMN1; SMN2CYP3A4CYP2C9CYP2C19MEN1
SCHEMBL7016154 0.89 MEN1 (0.45) HPGDLMNASMN1; SMN2CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0733633-B1 Heterocyclic compounds, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-05-28 EP disclosed
US-5753664-A ANTITUMOR AGENTS, PYRIMIDONES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-05-19 US disclosed
EP-0733633-A1 Heterocyclic compounds, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-09-25 EP disclosed