SCHEMBL7014606

SCHEMBL7014606

C=CCN(C(N)=S)c1cccc(CN(C(=O)OC(C)(C)C)c2cc(N3CCOCC3)cc(CSc3nnc(CC)s3)n2)c1

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NPY1R P25929 5/20 0.32
AOC3 Q16853 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7022375 0.86 NPY1R (0.36) NPY1RAOC3
SCHEMBL7012282 0.86 HTR2C (0.38) NPY1R
SCHEMBL7014609 0.85 AKT1 (0.35) NPY1R
SCHEMBL7010773 0.85 NPY1R (0.35) NPY1RAOC3
SCHEMBL7021884 0.84 AKT1 (0.35) NPY1R
SCHEMBL7016803 0.84 MRGPRX4 (0.41) NPY1R
SCHEMBL7016610 0.81 NPY1R (0.35) NPY1R
SCHEMBL7022451 0.80 NPY1R (0.36) NPY1R
SCHEMBL7018031 0.79 TSHR (0.35) NPY1R
SCHEMBL7013783 0.79 NPY1R (0.46) NPY1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0889034-B1 AMINOPYRIDINE DERIVATIVES BANYU PHARMA CO LTD (JP) 2003-09-17 EP disclosed
US-6011039-A USEFUL AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS; TREATING HYPERPHAGIA, OBESITY OR DIABETES BANYU PHARMACEUTICAL CO., LTD. (JP) 2000-01-04 US disclosed
EP-0889034-A1 AMINOPYRIDINE DERIVATIVES BANYU PHARMACEUTICAL CO., LTD. (JP) 1999-01-07 EP disclosed