Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 9/20 | 0.66 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | IDH1 | O75874 | 10/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018086 | 0.87 | LCK (0.65) | LCKJAK2JAK3IDH1 | |
| SCHEMBL7020339 | 0.80 | LCK (1.00) | LCKJAK2JAK3 | |
| SCHEMBL7022505 | 0.80 | LCK (1.00) | LCKJAK2JAK3 | |
| SCHEMBL3154288 | 0.76 | AURKA (0.54) | LCKJAK2JAK3 | |
| SCHEMBL7016983 | 0.75 | LCK (0.87) | LCKJAK2JAK3IDH1 | |
| SCHEMBL7569390 | 0.74 | LCK (0.85) | LCKJAK2JAK3 | |
| SCHEMBL7025084 | 0.74 | LCK (0.85) | LCKJAK2JAK3 | |
| SCHEMBL7017465 | 0.74 | LCK (0.89) | LCKJAK2JAK3IDH1 | |
| SCHEMBL7025239 | 0.74 | LCK (1.00) | LCKJAK2JAK3IDH1 | |
| SCHEMBL14629467 | 0.73 | HTR7 (0.57) | LCKJAK2JAK3IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-B1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2003-11-12 | — | — | EP | disclosed |
| US-6498165-B1 | PYRIMIDINE COMPOUNDS; PROPHYLAXIS AND TREATMENT OF SUCH AS IMMUNE DISEASES, HYPERPROLIFERATIVE DISORDERS, CANCER, ANGIOGENSIS, ATHEROSCELEROSIS, GRAFT REJECTION, RHEUMATOID ARTHRITIS, PSORIASIS | MERCK & CO., INC. | 2002-12-24 | — | — | US | disclosed |