SCHEMBL7015045

SCHEMBL7015045

Cc1nc2c(OCc3c(Cl)ccc(S(=O)(=O)N4CCC[C@H]4C(=O)N4CCN(C(=O)c5ccc(C#N)cc5)CC4)c3Cl)cccn2c1Cl

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RORC P51449 17/20 0.49
BDKRB2 P30411 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7015043 1.00 RORC (0.49) RORCBDKRB2
SCHEMBL7010095 0.95 RORC (0.49) RORCBDKRB2
SCHEMBL7010094 0.95 RORC (0.49) RORCBDKRB2
SCHEMBL7014875 0.91 RORC (0.51) RORCBDKRB2
SCHEMBL7011654 0.91 RORC (0.51) RORCBDKRB2
SCHEMBL7011656 0.91 RORC (0.51) RORCBDKRB2
SCHEMBL7016579 0.89 RORC (0.49) RORCBDKRB2
SCHEMBL7016577 0.89 RORC (0.49) RORCBDKRB2
SCHEMBL7018105 0.88 RORC (0.49) RORCBDKRB2
SCHEMBL7018107 0.88 RORC (0.49) RORCBDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0991650-B1 NOVEL N-BENZENESULPHONYL-L-PROLINE COMPOUNDS, PREPARATION METHOD AND USE IN THERAPY FOURNIER IND & SANTE (FR) 2003-09-10 EP disclosed
EP-0991650-A1 NOVEL N-BENZENESULPHONYL-L-PROLINE COMPOUNDS, PREPARATION METHOD AND USE IN THERAPY FOURNIER INDUSTRIE ET SANTE (FR) 2000-04-12 EP disclosed
WO-1999000387-A1 NOVEL N-BENZENESULPHONYL-L-PROLINE COMPOUNDS, PREPARATION METHOD AND USE IN THERAPY FOURNIER INDUSTRIE ET SANTE (FR) 1999-01-07 WO disclosed