Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 9/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | NPY1R | P25929 | 8/20 | 0.39 |
| ▸ | JAK1 | P23458 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL647566 | 0.93 | NPY1R (0.46) | JAK3JAK2NPY1RJAK1 | |
| SCHEMBL7016594 | 0.90 | MAPT (0.34) | JAK3JAK2NPY1RJAK1TP53 | |
| SCHEMBL7016779 | 0.86 | NPY1R (0.46) | JAK3JAK2NPY1RJAK1 | |
| SCHEMBL7018703 | 0.86 | NPY1R (0.45) | JAK3JAK2NPY1RJAK1 | |
| SCHEMBL7011726 | 0.85 | NPY1R (0.51) | JAK3JAK2NPY1RJAK1 | |
| SCHEMBL7010930 | 0.85 | NPY1R (0.46) | JAK3JAK2NPY1RJAK1 | |
| SCHEMBL7017021 | 0.85 | NPY1R (0.46) | JAK3JAK2NPY1RJAK1 | |
| SCHEMBL7011569 | 0.84 | NPY1R (0.48) | JAK3JAK2NPY1RJAK1SMN1; SMN2 | |
| SCHEMBL7012025 | 0.84 | NPY1R (0.45) | JAK3JAK2NPY1RJAK1 | |
| SCHEMBL7012625 | 0.84 | NPY1R (0.51) | NPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889034-B1 | AMINOPYRIDINE DERIVATIVES | BANYU PHARMA CO LTD (JP) | 2003-09-17 | — | — | EP | disclosed |
| US-6011039-A | USEFUL AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS; TREATING HYPERPHAGIA, OBESITY OR DIABETES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2000-01-04 | — | — | US | disclosed |
| EP-0889034-A1 | AMINOPYRIDINE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1999-01-07 | — | — | EP | disclosed |