SCHEMBL7015259

SCHEMBL7015259

CCN(CC)CCCCC[O]

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PAOX Q6QHF9 1/20 0.39
SIGMAR1 Q99720 2/20 0.39
HRH4 Q9H3N8 2/20 0.37
HRH3 Q9Y5N1 2/20 0.37
ALDH1A1 P00352 2/20 0.37
SLC6A4 P31645 2/20 0.37
SLC6A2 P23975 1/20 0.37
HRH1 P35367 1/20 0.37
NPSR1 Q6W5P4 1/20 0.36
KCNH2 Q12809 2/20 0.35
APOBEC3A P31941 1/20 0.35
APOBEC3G Q9HC16 1/20 0.35
SLC2A1 P11166 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6263119 1.00 PAOX (0.39) PAOXSIGMAR1HRH4HRH3ALDH1A1
SCHEMBL9074 0.97 SIGMAR1 (0.40) PAOXSIGMAR1HRH4HRH3ALDH1A1
SCHEMBL9241 0.88
SCHEMBL2142541 0.85 SIGMAR1 (0.46) PAOXSIGMAR1HRH4HRH3ALDH1A1
SCHEMBL2141035 0.85 SIGMAR1 (0.46) PAOXSIGMAR1HRH4HRH3ALDH1A1
SCHEMBL1313942 0.85 SIGMAR1 (0.46) PAOXSIGMAR1HRH4HRH3ALDH1A1
SCHEMBL28723073 0.85 SIGMAR1 (0.46) PAOXSIGMAR1HRH4HRH3ALDH1A1
SCHEMBL2564528 0.85 SIGMAR1 (0.46) PAOXSIGMAR1HRH4HRH3ALDH1A1
SCHEMBL2137948 0.85 SIGMAR1 (0.46) PAOXSIGMAR1HRH4HRH3ALDH1A1
SCHEMBL6366393 0.85 SIGMAR1 (0.46) PAOXSIGMAR1HRH4HRH3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0815859-B1 INTIMAL THICKENING INHIBITORS TAIHO PHARMACEUTICAL CO LTD (JP) 2003-06-18 EP disclosed
US-5977130-A CARDIOVASCULAR DISORDERS TAIHO PHARMEUTICAL CO., LTD. (JP) 1999-11-02 US disclosed
EP-0815859-A1 INTIMAL THICKENING INHIBITORS TAIHO PHARMACEUTICAL COMPANY LIMITED (JP) 1998-01-07 EP disclosed
US-5703075-A Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones PHARMACIA & UPJOHN COMPANY (US) 1997-12-30 US disclosed
EP-0489877-B1 ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 2-AMINO-6-PHENYL-4H-PYRAN-4-ONES UPJOHN CO (US) 1995-09-20 EP disclosed
US-5302613-A Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones THE UPJOHN COMPANY (US) 1994-04-12 US disclosed
US-5252735-A Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones THE UPJOHN COMPANY (US) 1993-10-12 US disclosed
EP-0489877-A1 ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 2-AMINO-6-PHENYL-4H-PYRAN-4-ONES. UPJOHN CO (US) 1992-06-17 EP disclosed
WO-1992000290-A1 ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 2-AMINO-6-PHENYL-4H-PYRAN-4-ONES THE UPJOHN COMPANY (US) 1992-01-09 WO disclosed
WO-1991019707-A2 ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES THE UPJOHN COMPANY (US) 1991-12-26 WO disclosed
EP-0459983-A1 ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES PHARMACIA & UPJOHN COMPANY (US) 1991-12-11 EP disclosed
WO-1990006921-A1 ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES THE UPJOHN COMPANY (US) 1990-06-28 WO disclosed