Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | PKLR | P30613 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015338 | 1.00 | GAA (0.43) | GAAKMT2AEGLN1NPC1ATM | |
| SCHEMBL7106149 | 0.88 | GAA (0.43) | GAAKMT2AEGLN1NPC1ATM | |
| SCHEMBL7017008 | 0.79 | ADORA2B (0.38) | GAAPDE7A | |
| SCHEMBL7017005 | 0.79 | ADORA2B (0.38) | GAAPDE7A | |
| SCHEMBL7023021 | 0.76 | ERCC1 (0.48) | — | |
| SCHEMBL7020394 | 0.75 | GAA (0.44) | GAAKMT2AEGLN1NPC1ATM | |
| SCHEMBL7020396 | 0.75 | GAA (0.44) | GAAKMT2AEGLN1NPC1ATM | |
| SCHEMBL6295499 | 0.75 | GAA (0.59) | GAAKMT2AEGLN1NPC1ATM | |
| SCHEMBL7014450 | 0.74 | GAA (0.43) | GAAKMT2AEGLN1NPC1ATM | |
| SCHEMBL6294357 | 0.72 | GAA (0.56) | GAAKMT2ANPC1ATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1357114-A1 | Substituted pyrimidin-2,4(1H,3H)-diones as inhibitors of Matrix Metalloproteinases (MMP) | IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE) | 2003-10-29 | — | — | EP | disclosed |