Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.30 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.30 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.30 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.30 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17285631 | 0.83 | HRH3 (0.41) | NPC1HRH3TMEM97CARM1PRMT6 | |
| SCHEMBL24607305 | 0.82 | NPC1 (0.48) | NPC1HRH3TMEM97CARM1PRMT6 | |
| SCHEMBL22794637 | 0.78 | GNAO1 (0.46) | NPC1HRH3 | |
| SCHEMBL25654229 | 0.77 | NPC1 (0.36) | NPC1TAAR1 | |
| SCHEMBL22856482 | 0.77 | HRH3 (0.43) | NPC1HRH3CARM1PRMT6 | |
| SCHEMBL12049582 | 0.77 | NPC1 (0.42) | NPC1HRH3TAAR1 | |
| SCHEMBL8860927 | 0.76 | NPC1 (0.31) | NPC1HRH3TMEM97CARM1PRMT6 | |
| SCHEMBL22703730 | 0.76 | TAAR1 (0.36) | NPC1TMEM97SIGMAR1TAAR1 | |
| SCHEMBL8860627 | 0.75 | — | — | |
| SCHEMBL13179149 | 0.75 | NPC1 (0.36) | NPC1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278741-A1 | MUSCARINIC AGONISTS | Acadia Pharmaceuticals Inc. (US) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001083472-A1 | MUSCARINIC AGONISTS | ACADIA PHARMACEUTICALS, INC. (US) | 2001-11-08 | — | — | WO | disclosed |