Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.40 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 11/20 | 0.37 |
| ▸ | TOP2B | Q02880 | 9/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TOP1 | P11387 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012922 | 0.89 | KDM4E (0.36) | ALDH1A1KDM4EADRA2BMAPK1HPGD | |
| SCHEMBL6802345 | 0.82 | PIM1 (0.43) | PIM1GSK3AGSK3BPIM3CSNK1G1 | |
| SCHEMBL7011369 | 0.71 | PRKD3 (0.43) | PIM1GSK3AGSK3BPIM3ALDH1A1 | |
| SCHEMBL6807190 | 0.70 | KDM4E (0.37) | PIM1GSK3AGSK3BPIM3CSNK1G1 | |
| SCHEMBL6807192 | 0.70 | KDM4E (0.37) | PIM1GSK3AGSK3BPIM3CSNK1G1 | |
| SCHEMBL6800235 | 0.69 | PIM1 (0.56) | PIM1GSK3AGSK3BPIM3CSNK1G1 | |
| SCHEMBL7012086 | 0.69 | KMT2A (0.43) | PIM1GSK3AGSK3BPIM3CHRM2 | |
| SCHEMBL7013934 | 0.69 | PRKD3 (0.39) | PIM1GSK3AGSK3BPIM3ALDH1A1 | |
| SCHEMBL6803349 | 0.68 | PIM1 (0.44) | PIM1GSK3AGSK3BPIM3CSNK1G1 | |
| SCHEMBL7014855 | 0.67 | TOP1 (0.42) | PIM1GSK3AGSK3BPIM3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028950-B1 | 7-SUBSTITUTED QUINAZOLIN-2,4-DIONES USEFUL AS ANTIBACTERIAL AGENTS | WARNER LAMBERT CO (US) | 2003-05-02 | — | — | EP | claimed |