Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 18/20 | 0.69 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.50 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.50 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.50 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7007751 | 0.91 | PLA2G1B (0.84) | PLA2G1BPLA2G2APLA2G10PLA2G5PLA2G2E | |
| SCHEMBL7010224 | 0.84 | PLA2G1B (0.60) | PLA2G1BPLA2G2A | |
| SCHEMBL7011505 | 0.81 | PLA2G1B (0.65) | PLA2G1BPLA2G2APLA2G10PLA2G5PLA2G2E | |
| SCHEMBL7006970 | 0.80 | PLA2G1B (0.71) | PLA2G1BPLA2G2APLA2G10PLA2G5PLA2G2E | |
| SCHEMBL7018369 | 0.78 | PLA2G1B (1.00) | PLA2G1BPLA2G2APLA2G10PLA2G5PLA2G2E | |
| SCHEMBL7102348 | 0.78 | PLA2G1B (0.84) | PLA2G1BPLA2G2APLA2G10PLA2G5PLA2G2E | |
| SCHEMBL7013779 | 0.76 | PLA2G1B (0.83) | PLA2G1BPLA2G2APLA2G10PLA2G5PLA2G2E | |
| SCHEMBL7013044 | 0.74 | PLA2G1B (0.61) | PLA2G1BPLA2G2APLA2G10PLA2G5PLA2G2E | |
| SCHEMBL7012864 | 0.74 | PLA2G1B (0.73) | PLA2G1BPLA2G2APLA2G10PLA2G5PLA2G2E | |
| SCHEMBL7010786 | 0.72 | PLA2G1B (0.70) | PLA2G1BPLA2G2APLA2G10PLA2G5PLA2G2E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645976-B1 | Nonpancreatic secretory phospholipase (sPLA2) supressors such as 2-(3-Benzyl-8-hydroxy-2-ethylindolizin-1-yl)acetamide, administered to control release of fatty acid and prevent the arachidonic acid cascade; septic shock | ELI LILLY AND COMPANY | 2003-11-11 | — | — | US | disclosed |
| EP-0772596-B1 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-10-01 | — | — | EP | disclosed |