Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012864 | 0.91 | PLA2G1B (0.73) | PLA2G1BPLA2G2A | |
| SCHEMBL7016187 | 0.84 | PLA2G1B (0.69) | PLA2G1BPLA2G2A | |
| SCHEMBL7007751 | 0.74 | PLA2G1B (0.84) | PLA2G1BPLA2G2A | |
| SCHEMBL9081375 | 0.69 | PLA2G1B (0.71) | PLA2G1BPLA2G2A | |
| SCHEMBL9081355 | 0.67 | PLA2G1B (0.77) | PLA2G1BPLA2G2A | |
| SCHEMBL9080540 | 0.67 | PLA2G1B (0.84) | PLA2G1BPLA2G2A | |
| Hydrochloric Acid SCHEMBL8159146 | 0.67 | L3MBTL1 (0.54) | PLA2G1B | |
| SCHEMBL9081350 | 0.66 | PLA2G1B (0.74) | PLA2G1BPLA2G2A | |
| SCHEMBL9083142 | 0.66 | PLA2G1B (0.62) | PLA2G1BPLA2G2A | |
| SCHEMBL7011505 | 0.65 | PLA2G1B (0.65) | PLA2G1BPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645976-B1 | Nonpancreatic secretory phospholipase (sPLA2) supressors such as 2-(3-Benzyl-8-hydroxy-2-ethylindolizin-1-yl)acetamide, administered to control release of fatty acid and prevent the arachidonic acid cascade; septic shock | ELI LILLY AND COMPANY | 2003-11-11 | — | — | US | disclosed |
| EP-0772596-B1 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-10-01 | — | — | EP | disclosed |