Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | RGS12 | O14924 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7016261 | 1.00 | USP2 (0.34) | USP2POLBKEAP1NFE2L2SMN1; SMN2 | |
| SCHEMBL7014592 | 0.88 | FEN1 (0.35) | USP2POLBKEAP1NFE2L2SMN1; SMN2 | |
| SCHEMBL7014590 | 0.88 | FEN1 (0.35) | USP2POLBKEAP1NFE2L2SMN1; SMN2 | |
| SCHEMBL7105873 | 0.80 | USP2 (0.38) | USP2POLBKEAP1NFE2L2SMN1; SMN2 | |
| SCHEMBL7258493 | 0.80 | USP2 (0.38) | USP2POLBKEAP1NFE2L2SMN1; SMN2 | |
| SCHEMBL7097369 | 0.78 | USP2 (0.33) | USP2POLBKEAP1NFE2L2SMN1; SMN2 | |
| SCHEMBL7015194 | 0.77 | ADORA3 (0.37) | PKMHPGDKMT2AKDM4EADORA2A | |
| SCHEMBL7015193 | 0.77 | ADORA3 (0.37) | PKMHPGDKMT2AKDM4EADORA2A | |
| SCHEMBL7023095 | 0.75 | ADORA3 (0.32) | HPGDKDM4EADORA2AADORA2BADORA3 | |
| SCHEMBL7023092 | 0.75 | ADORA3 (0.32) | HPGDKDM4EADORA2AADORA2BADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003089416-A1 | SUBSTITUTED PYRIMIDINE-2,4(1H,3H)-DIONES FOR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | IBFB GMBH (DE) | 2003-10-30 | — | — | WO | disclosed |
| EP-1357114-A1 | Substituted pyrimidin-2,4(1H,3H)-diones as inhibitors of Matrix Metalloproteinases (MMP) | IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE) | 2003-10-29 | — | — | EP | disclosed |