Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GALR3 | O60755 | 1/20 | 0.30 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.30 |
| ▸ | GPR183 | P32249 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7011309 | 0.80 | KAT2B (0.37) | SMN1; SMN2NPC1LMNARAB9ACYP1A2 | |
| SCHEMBL7017794 | 0.74 | NPC1 (0.33) | SMN1; SMN2NPC1LMNARAB9ACYP1A2 | |
| SCHEMBL24498709 | 0.72 | SMN1; SMN2 (0.39) | SMN1; SMN2NPSR1NPC1LMNARAB9A | |
| SCHEMBL7013194 | 0.72 | LMNA (0.33) | SMN1; SMN2NPC1LMNARAB9ACYP1A2 | |
| SCHEMBL17582551 | 0.65 | PIK3CD (0.46) | SMN1; SMN2NPC1LMNARAB9ACYP3A4 | |
| SCHEMBL8550187 | 0.64 | TSHR (0.38) | SMN1; SMN2NPSR1NPC1LMNARAB9A | |
| SCHEMBL8542209 | 0.64 | SMN1; SMN2 (0.38) | SMN1; SMN2NPSR1NPC1LMNARAB9A | |
| SCHEMBL14012593 | 0.62 | TSHR (0.39) | SMN1; SMN2NPSR1NPC1LMNARAB9A | |
| SCHEMBL9237010 | 0.61 | SMN1; SMN2 (0.38) | SMN1; SMN2NPSR1NPC1LMNARAB9A | |
| SCHEMBL12410744 | 0.60 | TSHR (0.41) | SMN1; SMN2NPSR1NPC1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| US-5753664-A | ANTITUMOR AGENTS, PYRIMIDONES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |