Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 12/20 | 0.62 |
| ▸ | HTR1B | P28222 | 12/20 | 0.62 |
| ▸ | HTR1A | P08908 | 3/20 | 0.62 |
| ▸ | HTR1F | P30939 | 3/20 | 0.62 |
| ▸ | NOS3 | P29474 | 3/20 | 0.58 |
| ▸ | NOS1 | P29475 | 3/20 | 0.58 |
| ▸ | NOS2 | P35228 | 1/20 | 0.58 |
| ▸ | HTR6 | P50406 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.49 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7481861 | 0.88 | HTR1D (0.62) | HTR1DHTR1BHTR1AHTR1FNOS3 | |
| Fumaric Acid SCHEMBL7481870 | 0.88 | HTR1D (0.62) | HTR1DHTR1BHTR1AHTR1FNOS3 | |
| SCHEMBL7009508 | 0.83 | HTR1D (0.83) | HTR1DHTR1BHTR1AHTR1FHTR6 | |
| SCHEMBL7480742 | 0.83 | HTR1D (0.61) | HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL7478148 | 0.83 | HTR1D (0.55) | HTR1DHTR1BHTR1AHTR1FNOS3 | |
| SCHEMBL7479138 | 0.83 | HTR1D (0.59) | HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL7484610 | 0.83 | HTR1D (0.55) | HTR1DHTR1BHTR1AHTR1FNOS3 | |
| SCHEMBL1122273 | 0.82 | HTR1D (0.64) | HTR1DHTR1BHTR1AHTR1FNOS3 | |
| SCHEMBL7017007 | 0.81 | HTR1D (0.85) | HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL7486909 | 0.81 | HTR1D (0.62) | HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089993-B1 | 5-HT1F AGONISTS | LILLY CO ELI (US) | 2003-10-22 | — | — | EP | disclosed |
| US-6358972-B1 | FOR THERAPY OF MIGRAINE | ELI LILLY AND COMPANY | 2002-03-19 | — | — | US | disclosed |