Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5749857 | 0.97 | LMNA (0.30) | LMNATSHRKDM4EMAPT | |
| SCHEMBL23142615 | 0.97 | LMNA (0.30) | LMNATSHRKDM4EMAPT | |
| SCHEMBL5409875 | 0.97 | LMNA (0.32) | LMNATSHRKDM4EMAPT | |
| SCHEMBL9463108 | 0.94 | LMNA (0.31) | LMNATSHRKDM4EMAPT | |
| SCHEMBL2679027 | 0.94 | HSD17B10 (0.33) | LMNATSHRKDM4EMAPT | |
| SCHEMBL11572261 | 0.91 | LMNA (0.30) | LMNATSHRKDM4EMAPT | |
| SCHEMBL17675058 | 0.91 | LMNA (0.30) | LMNATSHRKDM4EMAPT | |
| SCHEMBL5690694 | 0.84 | — | — | |
| SCHEMBL8008844 | 0.82 | — | — | |
| SCHEMBL10709551 | 0.78 | LMNA (0.35) | LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362054-A1 | BICYCLIC PYRIMIDINE MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002064599-A1 | BICYCLIC PYRIMIDINE MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | disclosed |