Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 1/20 | 0.62 |
| ▸ | SRC | P12931 | 18/20 | 0.61 |
| ▸ | EGFR | P00533 | 16/20 | 0.61 |
| ▸ | ABL1 | P00519 | 15/20 | 0.61 |
| ▸ | ABL2 | P42684 | 15/20 | 0.61 |
| ▸ | LCK | P06239 | 4/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | NPM1 | P06748 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | LYN | P07948 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | MET | P08581 | 1/20 | 0.52 |
| ▸ | ROS1 | P08922 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | BCR | P11274 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27379837 | 0.93 | RIPK2 (0.65) | RIPK2SRCEGFRABL1ABL2 | |
| SCHEMBL7020683 | 0.91 | SRC (0.74) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL7023282 | 0.90 | SRC (0.72) | RIPK2SRCEGFRABL1ABL2 | |
| SCHEMBL7025034 | 0.89 | EGFR (0.75) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL8098846 | 0.88 | SRC (0.75) | RIPK2SRCEGFRABL1ABL2 | |
| SCHEMBL7023842 | 0.88 | RIPK2 (0.68) | RIPK2SRCEGFRABL1ABL2 | |
| SCHEMBL7023465 | 0.85 | SRC (0.72) | RIPK2SRCEGFRABL1ABL2 | |
| SCHEMBL7018931 | 0.85 | IGF1R (0.69) | RIPK2SRCEGFRABL1ABL2 | |
| SCHEMBL7023375 | 0.85 | SRC (0.78) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL7023438 | 0.85 | SRC (0.75) | RIPK2SRCEGFRABL1ABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888353-B1 | N-7-HETEROCYCLYL PYRROLO [2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2003-07-09 | — | — | EP | disclosed |