Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 18/20 | 0.75 |
| ▸ | EGFR | P00533 | 12/20 | 0.75 |
| ▸ | ABL1 | P00519 | 11/20 | 0.75 |
| ▸ | ABL2 | P42684 | 11/20 | 0.75 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.64 |
| ▸ | LCK | P06239 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.54 |
| ▸ | INSR | P06213 | 1/20 | 0.54 |
| ▸ | NPM1 | P06748 | 1/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | LYN | P07948 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | IGF1R | P08069 | 1/20 | 0.54 |
| ▸ | MET | P08581 | 1/20 | 0.54 |
| ▸ | ROS1 | P08922 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | BCR | P11274 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8098935 | 0.91 | SRC (0.90) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL8098919 | 0.89 | SRC (0.90) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL8108104 | 0.89 | SRC (0.91) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL7016480 | 0.88 | RIPK2 (0.62) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL27379837 | 0.87 | RIPK2 (0.65) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL28667953 | 0.86 | SRC (0.79) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL29503488 | 0.85 | SRC (0.66) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL21084200 | 0.85 | SRC (0.66) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL15708998 | 0.85 | SRC (0.75) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL15708999 | 0.85 | SRC (0.75) | SRCEGFRABL1ABL2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6051577-A | TYROSINE INHIBITORS; BONE DISORDERS | NOVARTIS AG (CH) | 2000-04-18 | — | — | US | disclosed |