Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | DGKA | P23743 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.41 |
| ▸ | CASP2 | P42575 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29273400 | 0.92 | CA12 (0.45) | EPHX2ALDH1A1TSHRS1PR2S1PR4 | |
| SCHEMBL19032548 | 0.92 | CA12 (0.45) | EPHX2ALDH1A1TSHRS1PR2S1PR4 | |
| SCHEMBL6347343 | 0.88 | PAOX (0.44) | EPHX2ALDH1A1TSHRMAOAMAOB | |
| SCHEMBL31226873 | 0.88 | EPHX2 (0.44) | EPHX2TSHRMAOAMAOBCA12 | |
| SCHEMBL20589911 | 0.86 | MAPK1 (0.50) | ALDH1A1TSHRMAPTMAPK1LMNA | |
| SCHEMBL30836838 | 0.85 | MAPK1 (0.49) | ALDH1A1TSHRMAPTMAPK1LMNA | |
| SCHEMBL3666005 | 0.84 | CA12 (0.42) | EPHX2ALDH1A1TSHRMAOAMAOB | |
| SCHEMBL3121472 | 0.84 | DGKA (0.57) | ALDH1A1TSHRDGKAMAPTMAPK1 | |
| SCHEMBL9985650 | 0.84 | DGKA (0.57) | ALDH1A1TSHRDGKAMAPTMAPK1 | |
| SCHEMBL3662225 | 0.84 | DGKA (0.57) | ALDH1A1TSHRDGKAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1048651-B1 | NITROGEN-CONTAINING TETRACYCLIC COMPOUNDS | TAISHO PHARMACEUTICAL CO LTD (JP) | 2003-05-14 | — | — | EP | disclosed |
| US-6281355-B1 | Nitrogen-containing tetracyclic compounds | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2001-08-28 | — | — | US | disclosed |
| EP-1048651-A1 | NITROGEN-CONTAINING TETRACYCLIC COMPOUNDS | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2000-11-02 | — | — | EP | disclosed |