Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 18/20 | 0.48 |
| ▸ | ITGAV | P06756 | 18/20 | 0.48 |
| ▸ | ITGB1 | P05556 | 7/20 | 0.48 |
| ▸ | ITGB5 | P18084 | 4/20 | 0.48 |
| ▸ | ITGB6 | P18564 | 3/20 | 0.48 |
| ▸ | MDM4 | O15151 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.45 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6802228 | 0.97 | ITGB3 (0.48) | ITGB3ITGAVITGB1ITGB5ITGB6 | |
| SCHEMBL6804811 | 0.91 | ITGB3 (0.48) | ITGB3ITGAVITGB1ITGB5ITGB6 | |
| SCHEMBL6804856 | 0.90 | ITGB3 (0.42) | ITGB3ITGAVITGB1ITGB5ITGB6 | |
| SCHEMBL6809475 | 0.89 | ITGB3 (0.49) | ITGB3ITGAVITGB1ITGB5ITGB6 | |
| SCHEMBL7018419 | 0.88 | ITGB3 (0.42) | ITGB3ITGAVITGB1ITGB5ITGB6 | |
| Trifluoroacetic Acid SCHEMBL6806426 | 0.88 | ITGB3 (0.48) | ITGB3ITGAVITGB1ITGB5ITGB6 | |
| Trifluoroacetic Acid SCHEMBL6804895 | 0.86 | ITGB3 (0.49) | ITGB3ITGAVITGB1ITGB5ITGB6 | |
| SCHEMBL6804884 | 0.86 | ITGB3 (0.51) | ITGB3ITGAVITGB1ITGB5ITGB6 | |
| Trifluoroacetic Acid SCHEMBL6809448 | 0.83 | ITGB3 (0.50) | ITGB3ITGAVITGB1ITGB5ITGB6 | |
| SCHEMBL6805351 | 0.82 | ITGB3 (0.46) | ITGB3ITGAVITGB1ITGB5ITGB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313705-A1 | GEM-SUBSTITUTED ALPHA V BETA 3 INTEGRIN ANTAGONISTS | Pharmacia Corporation (US) | 2003-05-28 | — | — | EP | claimed |
| US-6531494-B1 | Gem-substituted αvβ3 antagonists | PHARMACIA CORPORATION | 2003-03-11 | — | — | US | claimed |
| WO-2002018340-A1 | GEM-SUBSTITUTED α v β 3 INTEGRIN ANTAGONISTS | PHARMACIA CORPORATION (US) | 2002-03-07 | — | — | WO | claimed |
| EP-1313705-A1 | GEM-SUBSTITUTED ALPHA V BETA 3 INTEGRIN ANTAGONISTS | Pharmacia Corporation (US) | 2003-05-28 | — | — | EP | disclosed |
| US-6531494-B1 | Gem-substituted αvβ3 antagonists | PHARMACIA CORPORATION | 2003-03-11 | — | — | US | disclosed |
| WO-2002018340-A1 | GEM-SUBSTITUTED α v β 3 INTEGRIN ANTAGONISTS | PHARMACIA CORPORATION (US) | 2002-03-07 | — | — | WO | disclosed |