Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599847 | 0.95 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL7012611 | 0.92 | CRHR1 (0.40) | CRHR1 | |
| SCHEMBL7018321 | 0.90 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL7019319 | 0.88 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL7016136 | 0.86 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL7018159 | 0.86 | CRHR1 (0.38) | CRHR1 | |
| SCHEMBL7016889 | 0.86 | CRHR1 (0.37) | CRHR1 | |
| SCHEMBL7015617 | 0.84 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL7016712 | 0.83 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL5866841 | 0.79 | CRHR1 (0.49) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920429-B1 | SUBSTITUTED PYRIDO- OR PYRIMIDO-CONTAINING 6,6- OR 6,7-BICYCLIC DERIVATIVES | PFIZER (US) | 2003-02-19 | — | — | EP | disclosed |
| US-6492520-B1 | COMPOUNDS (I) ARE CORTICOTROPIN RELEASING FACTOR (HORMONE) CRF (CRH) ANTAGONISTS. | PFIZER INC | 2002-12-10 | — | — | US | disclosed |
| EP-0920429-A1 | SUBSTITUTED PYRIDO- OR PYRIMIDO-CONTAINING 6,6- OR 6,7-BICYCLIC DERIVATIVES | PFIZER INC. (US) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998005661-A1 | SUBSTITUTED PYRIDO- OR PYRIMIDO-CONTAINING 6,6- OR 6,7-BICYCLIC DERIVATIVES | PFIZER INC. (US) | 1998-02-12 | — | — | WO | disclosed |