Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 17/20 | 0.75 |
| ▸ | EGFR | P00533 | 16/20 | 0.75 |
| ▸ | SRC | P12931 | 16/20 | 0.75 |
| ▸ | ABL2 | P42684 | 15/20 | 0.75 |
| ▸ | LCK | P06239 | 9/20 | 0.75 |
| ▸ | RET | P07949 | 4/20 | 0.65 |
| ▸ | IGF1R | P08069 | 4/20 | 0.65 |
| ▸ | JAK2 | O60674 | 3/20 | 0.65 |
| ▸ | INSR | P06213 | 3/20 | 0.65 |
| ▸ | KIT | P10721 | 3/20 | 0.65 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.65 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.65 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.65 |
| ▸ | KDR | P35968 | 3/20 | 0.65 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.65 |
| ▸ | KIF5B | P33176 | 3/20 | 0.65 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.65 |
| ▸ | NPM1 | P06748 | 2/20 | 0.65 |
| ▸ | CSF1R | P07333 | 2/20 | 0.65 |
| ▸ | LYN | P07948 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7022341 | 0.95 | ABL1 (0.69) | ABL1EGFRSRCABL2LCK | |
| SCHEMBL7019270 | 0.90 | SRC (0.63) | ABL1EGFRSRCABL2LCK | |
| SCHEMBL7018218 | 0.90 | SRC (0.64) | ABL1EGFRSRCABL2LCK | |
| SCHEMBL7017741 | 0.88 | EGFR (0.75) | ABL1EGFRSRCABL2LCK | |
| SCHEMBL8107017 | 0.86 | ABL1 (0.83) | ABL1EGFRSRCABL2LCK | |
| SCHEMBL8108556 | 0.86 | ABL1 (1.00) | ABL1EGFRSRCABL2LCK | |
| SCHEMBL7017737 | 0.85 | SRC (0.58) | ABL1EGFRSRCABL2LCK | |
| SCHEMBL7014534 | 0.84 | SRC (0.59) | ABL1EGFRSRCABL2LCK | |
| SCHEMBL7022376 | 0.83 | ABL1 (0.69) | ABL1EGFRSRCABL2LCK | |
| SCHEMBL8108060 | 0.83 | ABL1 (0.80) | ABL1EGFRSRCABL2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888353-B1 | N-7-HETEROCYCLYL PYRROLO [2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2003-07-09 | — | — | EP | claimed |
| US-6051577-A | TYROSINE INHIBITORS; BONE DISORDERS | NOVARTIS AG (CH) | 2000-04-18 | — | — | US | disclosed |