Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 19/20 | 0.69 |
| ▸ | EGFR | P00533 | 19/20 | 0.69 |
| ▸ | ABL2 | P42684 | 19/20 | 0.69 |
| ▸ | SRC | P12931 | 18/20 | 0.69 |
| ▸ | LCK | P06239 | 4/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7017741 | 0.95 | EGFR (0.75) | ABL1EGFRABL2SRCLCK | |
| SCHEMBL7015260 | 0.91 | SRC (0.60) | ABL1EGFRABL2SRCLCK | |
| SCHEMBL7022341 | 0.88 | ABL1 (0.69) | ABL1EGFRABL2SRCLCK | |
| SCHEMBL7014534 | 0.88 | SRC (0.59) | ABL1EGFRABL2SRCLCK | |
| SCHEMBL7023975 | 0.86 | EGFR (0.76) | ABL1EGFRABL2SRCLCK | |
| SCHEMBL8107232 | 0.86 | ABL1 (0.78) | ABL1EGFRABL2SRCLCK | |
| SCHEMBL7018756 | 0.86 | SRC (0.65) | ABL1EGFRABL2SRCLCK | |
| SCHEMBL7016791 | 0.83 | ABL1 (0.75) | ABL1EGFRABL2SRCLCK | |
| SCHEMBL7017737 | 0.83 | SRC (0.58) | ABL1EGFRABL2SRCLCK | |
| SCHEMBL7018218 | 0.83 | SRC (0.64) | ABL1EGFRABL2SRCLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888353-B1 | N-7-HETEROCYCLYL PYRROLO [2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2003-07-09 | — | — | EP | claimed |
| US-6051577-A | TYROSINE INHIBITORS; BONE DISORDERS | NOVARTIS AG (CH) | 2000-04-18 | — | — | US | disclosed |