Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC2 | O75106 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 2/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1626074 | 0.87 | AOC2 (0.43) | AOC2TRPV1HDAC1HDAC8MAP3K7 | |
| SCHEMBL1625609 | 0.84 | AOC2 (0.37) | AOC2TRPV1MAP3K7IRAK1IRAK4 | |
| SCHEMBL1626200 | 0.81 | AOC3 (0.50) | MAPT | |
| SCHEMBL1624237 | 0.79 | NOTUM (0.39) | TRPV1MAP3K7IRAK1IRAK4MEN1 | |
| SCHEMBL1626060 | 0.78 | AOC2 (0.37) | AOC2TRPV1MAP3K7IRAK1IRAK4 | |
| SCHEMBL3950318 | 0.77 | AOC2 (0.42) | AOC2TRPV1NAMPTMEN1KMT2A | |
| SCHEMBL1625018 | 0.76 | CTNNB1 (0.41) | TRPV1MAP3K7IRAK1IRAK4MEN1 | |
| SCHEMBL3946684 | 0.76 | RXFP1 (0.35) | AOC2TRPV1NAMPTMEN1KMT2A | |
| SCHEMBL1625413 | 0.75 | NOTUM (0.37) | AOC2TRPV1HDAC1HDAC8MAP3K7 | |
| SCHEMBL1625896 | 0.74 | AOC3 (0.46) | MAP3K7IRAK1IRAK4NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326864-A2 | ARYL OR HETEROARYL FUSED IMIDAZOLE COMPOUNDS AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS | PFIZER PHARMACEUTICALS INC. (JP) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032900-A2 | ARYL OR HETEROARYL FUSED IMIDAZOLE COMPOUNDS AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-04-25 | — | — | WO | disclosed |