Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28008650 | 0.88 | F2 (0.48) | F2CYP2D6CYP3A4CYP2C19SMN1; SMN2 | |
| SCHEMBL10815256 | 0.84 | CYP2C19 (0.45) | F2CYP2D6CYP3A4CYP2C19SMN1; SMN2 | |
| SCHEMBL28633131 | 0.82 | SMN1; SMN2 (0.51) | CYP2D6CYP3A4CYP2C19SMN1; SMN2CYP4F2 | |
| SCHEMBL2512047 | 0.80 | CYP3A4 (0.49) | CYP2D6CYP3A4CYP2C19SMN1; SMN2CYP4F2 | |
| SCHEMBL29069352 | 0.80 | ALDH1A1 (0.52) | CYP2D6CYP3A4CYP2C19SMN1; SMN2CYP4F2 | |
| SCHEMBL9067048 | 0.79 | F2 (0.45) | F2CYP2D6CYP3A4CYP2C19SMN1; SMN2 | |
| SCHEMBL28008276 | 0.79 | CYP3A4 (0.52) | F2CYP2D6CYP3A4CYP2C19SMN1; SMN2 | |
| SCHEMBL9680830 | 0.78 | CYP3A4 (0.48) | F2CYP2D6CYP3A4CYP2C19SMN1; SMN2 | |
| SCHEMBL8174744 | 0.78 | SMN1; SMN2 (0.51) | F2CYP2D6CYP3A4CYP2C19SMN1; SMN2 | |
| SCHEMBL8174741 | 0.78 | SMN1; SMN2 (0.51) | F2CYP2D6CYP3A4CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362054-A1 | BICYCLIC PYRIMIDINE MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002064599-A1 | BICYCLIC PYRIMIDINE MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | disclosed |