Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 11/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013924 | 0.93 | MAPT (0.45) | MEN1MAPTHTTKMT2ASMN1; SMN2 | |
| SCHEMBL7010973 | 0.92 | MAPT (0.44) | PDE5AMEN1MAPTHTTKMT2A | |
| SCHEMBL7011555 | 0.92 | PDE5A (0.44) | PDE5AMEN1MAPTHTTKMT2A | |
| SCHEMBL8177973 | 0.91 | PDE5A (0.51) | PDE5A | |
| SCHEMBL7018507 | 0.88 | PDE5A (0.48) | PDE5A | |
| SCHEMBL7020191 | 0.87 | PDE5A (0.48) | PDE5A | |
| SCHEMBL8178637 | 0.87 | PDE5A (0.45) | PDE5AMEN1MAPTHTTKMT2A | |
| SCHEMBL7009771 | 0.86 | PDE5A (0.50) | PDE5AMEN1MAPTHTTKMT2A | |
| SCHEMBL7015450 | 0.86 | PDE5A (0.48) | PDE5A | |
| SCHEMBL5778132 | 0.85 | KDM4E (0.47) | PDE5AMEN1MAPTHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |
| EP-0934321-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GmbH (DE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017668-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 1998-04-30 | — | — | WO | disclosed |