Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 8/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CNR1 | P21554 | 2/20 | 0.49 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018537 | 0.94 | KMT2A (0.48) | PDE5AMEN1KMT2AMAPTHTT | |
| SCHEMBL7019969 | 0.90 | MEN1 (0.49) | PDE5AMEN1KMT2AMAPTHTT | |
| SCHEMBL7010973 | 0.89 | MAPT (0.44) | PDE5AMEN1KMT2AMAPTHTT | |
| SCHEMBL8171021 | 0.89 | PDE5A (0.52) | PDE5AMEN1KMT2AMAPTHTT | |
| SCHEMBL7014043 | 0.89 | RNASEL (0.41) | PDE5AMEN1KMT2AMAPTHTT | |
| SCHEMBL7013924 | 0.88 | MAPT (0.45) | MEN1KMT2AMAPTHTTNPSR1 | |
| SCHEMBL7015052 | 0.87 | PDE4A (0.50) | PDE5AMEN1KMT2AMAPTHTT | |
| SCHEMBL7015240 | 0.87 | PDE4A (0.45) | PDE5AMEN1KMT2AMAPTHTT | |
| SCHEMBL7017130 | 0.86 | PDE5A (0.46) | PDE5AMEN1KMT2AMAPTHTT | |
| SCHEMBL8181825 | 0.85 | MEN1 (0.49) | PDE5AMEN1KMT2AMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |