Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | PDE4A | P27815 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | PDE5A | O76074 | 6/20 | 0.47 |
| ▸ | PDE2A | O00408 | 1/20 | 0.47 |
| ▸ | PDE1A | P54750 | 1/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.44 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7017588 | 0.91 | KDM4E (0.48) | LMNAALDH1A1HTTPDE4APDE4B | |
| SCHEMBL8170200 | 0.90 | PDE4A (0.56) | LMNAALDH1A1HTTPDE4APDE4B | |
| Bicarbonate SCHEMBL7014027 | 0.89 | ALDH1A1 (0.49) | LMNAALDH1A1HTTPDE4APDE4B | |
| Bicarbonate SCHEMBL7012727 | 0.89 | ALDH1A1 (0.49) | LMNAALDH1A1HTTPDE4APDE4B | |
| Bicarbonate SCHEMBL7020263 | 0.87 | PDE5A (0.46) | LMNAALDH1A1HTTPDE4BPDE4D | |
| Bicarbonate SCHEMBL7020099 | 0.87 | HTT (0.47) | LMNAALDH1A1HTTPDE4APDE4B | |
| Bicarbonate SCHEMBL7018662 | 0.86 | ALDH1A1 (0.47) | LMNAALDH1A1HTTPDE4APDE4B | |
| Bicarbonate SCHEMBL7020140 | 0.86 | TDP1 (0.42) | LMNAALDH1A1HTTPDE4APDE4B | |
| Bicarbonate SCHEMBL7017039 | 0.86 | PDE5A (0.59) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| Bicarbonate SCHEMBL7021903 | 0.85 | PDE5A (0.48) | PDE4BPDE4DPDE5ASMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |