Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 19/20 | 0.46 |
| ▸ | TCF7L2 | Q9NQB0 | 19/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7017521 | 0.93 | HRH4 (0.41) | CTNNB1TCF7L2HRH4 | |
| SCHEMBL7015106 | 0.90 | PDE5A (0.38) | CTNNB1TCF7L2HRH4 | |
| SCHEMBL8185688 | 0.90 | CTNNB1 (0.46) | CTNNB1TCF7L2 | |
| SCHEMBL7018532 | 0.90 | CTNNB1 (0.44) | CTNNB1TCF7L2HRH4 | |
| SCHEMBL7019169 | 0.90 | PDE5A (0.39) | CTNNB1TCF7L2 | |
| SCHEMBL7019931 | 0.89 | CTNNB1 (0.49) | CTNNB1TCF7L2HRH4 | |
| SCHEMBL7015708 | 0.89 | MET (0.39) | CTNNB1TCF7L2HRH4 | |
| SCHEMBL7014765 | 0.89 | PDE5A (0.48) | CTNNB1TCF7L2 | |
| SCHEMBL7018291 | 0.89 | PDE5A (0.43) | CTNNB1TCF7L2 | |
| SCHEMBL7015126 | 0.88 | PDE5A (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |
| EP-0934321-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GmbH (DE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017668-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 1998-04-30 | — | — | WO | disclosed |