Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 5/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6536139 | 0.85 | TP53 (0.53) | TP53NR1H4PPARAPKMALB | |
| SCHEMBL19994224 | 0.83 | TP53 (0.53) | TP53NR1H4ALOX5 | |
| SCHEMBL6484837 | 0.83 | NR1H4 (0.46) | NR1H4 | |
| SCHEMBL5607588 | 0.81 | MAPT (0.41) | PPARAL3MBTL1 | |
| SCHEMBL5607584 | 0.81 | MAPT (0.41) | PPARAL3MBTL1 | |
| SCHEMBL8413290 | 0.80 | TP53 (0.60) | TP53 | |
| SCHEMBL5083058 | 0.80 | TP53 (0.60) | TP53 | |
| SCHEMBL11250951 | 0.79 | NR1H4 (0.55) | TP53NR1H4 | |
| SCHEMBL5726523 | 0.79 | NR1H4 (0.46) | NR1H4PPARAALOX5L3MBTL1 | |
| SCHEMBL5726521 | 0.79 | NR1H4 (0.46) | NR1H4PPARAALOX5L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252150-B1 | HETEROCYCLIC DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2003-06-04 | — | — | EP | disclosed |
| EP-1252150-A1 | NOVEL HETEROCYCLIC DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Les Laboratoires Servier (FR) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001057002-A1 | NOVEL HETEROCYCLIC DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2001-08-09 | — | — | WO | disclosed |