Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7017331 | 1.00 | NPC1 (0.44) | NPC1RAB9AKMT2AMEN1RXFP1 | |
| SCHEMBL7012659 | 0.82 | NPC1 (0.46) | NPC1RAB9AKMT2ARXFP1TP53 | |
| SCHEMBL7012661 | 0.82 | NPC1 (0.46) | NPC1RAB9AKMT2ARXFP1TP53 | |
| Hydrochloric Acid SCHEMBL7018696 | 0.81 | KMT2A (0.43) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL7014764 | 0.78 | NPC1 (0.58) | NPC1RAB9AKMT2ARXFP1TP53 | |
| SCHEMBL7014766 | 0.78 | NPC1 (0.58) | NPC1RAB9AKMT2ARXFP1TP53 | |
| SCHEMBL7012937 | 0.76 | NPC1 (0.44) | NPC1RAB9AKMT2ARXFP1TP53 | |
| SCHEMBL7011884 | 0.76 | NPC1 (0.44) | NPC1RAB9AKMT2AMEN1RXFP1 | |
| SCHEMBL7011887 | 0.76 | NPC1 (0.44) | NPC1RAB9AKMT2AMEN1RXFP1 | |
| SCHEMBL7012252 | 0.75 | NPC1 (0.37) | NPC1RAB9AKMT2AMEN1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |