SCHEMBL7017340

SCHEMBL7017340

CN(C)C=CCc1ccc(Cl)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 4/20 0.46
MAPT P10636 3/20 0.43
CYP1A2 P05177 2/20 0.43
CYP2C19 P33261 2/20 0.43
HPGD P15428 1/20 0.43
ALOX12 P18054 1/20 0.43
AOC3 Q16853 1/20 0.42
LMNA P02545 2/20 0.42
MEN1 O00255 1/20 0.42
TTR P02766 1/20 0.42
POLB P06746 1/20 0.42
KMT2A Q03164 1/20 0.42
ALDH1A1 P00352 2/20 0.42
HTT P42858 2/20 0.42
RAB9A P51151 2/20 0.42
TAAR1 Q96RJ0 1/20 0.41
NPC1 O15118 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
PYCR1 P32322 1/20 0.39
IDO1 P14902 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28254555 0.79 TAAR1 (0.45) CYP1A2CYP2C19AOC3LMNAALDH1A1
SCHEMBL1420358 0.79 ESR1 (0.41) CYP2C19ALDH1A1TAAR1IDO1SLC6A2
SCHEMBL7980743 0.78 MAOB (0.61) KCNH2MAPTAOC3ALDH1A1TAAR1
SCHEMBL7980741 0.78 MAOB (0.61) KCNH2MAPTAOC3ALDH1A1TAAR1
SCHEMBL11005834 0.76 IDO1 (0.48) KCNH2AOC3MEN1KMT2AALDH1A1
SCHEMBL16234241 0.76 IDO1 (0.48) KCNH2AOC3MEN1KMT2AALDH1A1
SCHEMBL9136930 0.76 IDO1 (0.48) KCNH2AOC3MEN1KMT2AALDH1A1
SCHEMBL27645313 0.74 KCNH2 (0.53) KCNH2AOC3LMNATAAR1SMN1; SMN2
SCHEMBL9047923 0.71 IDO1 (0.43) KCNH2CYP1A2CYP2C19LMNAMEN1
SCHEMBL6207801 0.71 IDO1 (0.43) KCNH2LMNAALDH1A1HTTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2928470-A1 THIENOPYRIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS Siga Technologies, Inc. (US) 2015-10-14 EP disclosed
WO-2014089378-A1 THIENOPYRIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS SIGA TECHNOLOGIES, INC. (US) 2014-06-12 WO disclosed
EP-1349841-A2 ANILINOPYRIMIDINE DERIVATIVES AS IKK INHIBITORS AND COMPOSITIONS AND METHODS RELATED THERETO SIGNAL PHARMACEUTICALS, INC. (US) 2003-10-08 EP disclosed
WO-2002046171-A2 ANILINOPYRIMIDINE DERIVATIVES AS IKK INHIBITORS AND COMPOSITIONS AND METHODS RELATED THERETO SIGNAL PHARMACEUTICALS, INC. (US) 2002-06-13 WO disclosed